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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
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Published on: June 5, 2014

Circulating microRNAs in patients with active pulmonary tuberculosis.

Yurong Fu1, Zhengjun Yi, Xiaoyan Wu

  • 1Department of Medical Microbiology, Shandong Provincial Key Laboratory of Clinical Laboratory Diagnostics, Weifang Medical University, No. 7166, Baotong Xi (Western) Street, Weifang 261053, China. yifuyurong@163.com

Journal of Clinical Microbiology
|October 15, 2011
PubMed
Summary

Researchers identified specific microRNAs (miRNAs) in blood that change with active pulmonary tuberculosis (TB). Circulating miR-29a shows potential as a biomarker for diagnosing TB infection.

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • MicroRNAs (miRNAs) are crucial in pathogen-host interactions.
  • Circulating miRNAs are stable biomarkers for various conditions.
  • The role of circulating miRNAs in active pulmonary tuberculosis (TB) was previously unreported.

Purpose of the Study:

  • To investigate circulating miRNA expression in active pulmonary TB.
  • To identify potential miRNA biomarkers for TB detection.
  • To explore the functional roles of differentially expressed miRNAs in TB.

Main Methods:

  • Microarray-based expression profiling of serum miRNAs.
  • Real-time quantitative PCR for validation.
  • Receiver operating characteristic (ROC) curve analysis for diagnostic evaluation.
  • Bioinformatic analysis for pathway enrichment.

Main Results:

  • 92 miRNAs were significantly detected, with 59 downregulated and 33 upregulated in TB patients' serum.
  • Two miRNAs were elevated in both serum and sputum of TB patients.
  • Upregulated miR-29a demonstrated diagnostic potential for TB detection.
  • Enriched pathways included inflammatory response and cytoskeleton regulation.

Conclusions:

  • Circulating miRNA expression profiles differ in active pulmonary TB.
  • miR-29a is a promising circulating biomarker for active pulmonary TB detection.
  • These findings contribute to understanding miRNA's role in TB pathogenesis.