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Updated: May 28, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Sudden death from systemic rotavirus infection and detection of nonstructural rotavirus proteins

Ineko Nakano1, Koki Taniguchi, Hatsue Ishibashi-Ueda

  • 1Kyoto Min-iren Chuo Hospital, 16-1 Nishinokyo-Kasuga-cho, Nakagyo-ku, Kyoto 604-8453, Japan. inekoto@E-mail.jp

Journal of Clinical Microbiology
|October 15, 2011
PubMed

Insights

Rotavirus gastroenteritis can cause systemic infection and encephalopathy in children, extending beyond the gut. This study confirms rotavirus replication in multiple organs via viremia.

Area of Science:

  • Virology
  • Pediatric Pathology
  • Infectious Diseases

Background:

  • Rotavirus is a common cause of gastroenteritis in infants and children.
  • While primarily known for intestinal infections, systemic spread is less understood.

Observation:

  • A 2.5-year-old girl experienced sudden death during rotavirus gastroenteritis.
  • Autopsy revealed encephalopathy and evidence of rotavirus systemic infection.

Findings:

  • This study provides evidence of rotavirus replication in multiple organs beyond the gastrointestinal tract.
  • Viremia was identified as the mechanism for systemic rotavirus dissemination.

Implications:

  • Rotavirus infection can manifest as a systemic disease in children, leading to severe neurological complications.
  • These findings highlight the importance of considering systemic rotavirus involvement in pediatric cases of unexplained encephalopathy.

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