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Updated: May 28, 2026

11:13
Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
Published on: September 14, 2013
Tackling C difficile with environmental cleaning
1The Royal Free Hampstead NHS Trust, London.
Summary
New sporicidal wipes significantly reduced C. difficile rates by 72% in an acute care setting. This highlights the effectiveness of peracetic acid wipes over traditional chlorine-based disinfectants for environmental cleaning.
Area of Science:
- Infection Control
- Environmental Hygiene
- Healthcare-Associated Infections
Background:
- Traditional chlorine-based disinfectants pose risks due to high concentrations, causing irritation and corrosion.
- These limitations make chlorine products unsuitable for near-patient environments, leading to compliance issues.
- Peracetic acid and hydrogen peroxide-based products offer effective disinfection, even with heavy soiling.
Purpose of the Study:
- To evaluate the impact of peracetic acid sporicidal wipes on Clostridioides difficile (C. difficile) infection rates.
- To assess the efficacy of enhanced environmental cleaning in an acute care setting.
Main Methods:
- An 18-month observational study (2006-2010) monitored C. difficile rates in inpatients aged two years and older.
- A switch from chlorine-based to peracetic acid sporicidal wipes occurred in April 2008.
- Patient bed days were tracked to control for variations in patient volume.
Main Results:
- The mean C. difficile rate per 1000 patients decreased from six to two after introducing the wipes.
- Rates fell below two per 1000 patients in early 2009.
- A 72% overall reduction in C. difficile infection rates was observed.
Conclusions:
- Implementing peracetic acid sporicidal wipes led to a substantial decrease in C. difficile rates.
- Findings underscore the importance of revising environmental cleaning protocols to combat C. difficile.
- Enhanced disinfection strategies are crucial for acute care settings.
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