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Updated: May 28, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
The early development of pediatric intensive care
1Department of Anaesthesia, Royal Childrens Hospital, Melbourne, Australia. tckbrown@netspace.net.au
Abstract:
The polio epidemic in Copenhagen in 1952 was a significant stimulus to the development of Intensive Care. Eighty-five percent of the patients with respiratory involvement died despite the use of Cuirass negative pressure ventilators. After some controversy Ibsen, an anesthetist, was consulted. He found that many patients were dying with CO(2) retention. He advocated tracheostomy, suction, and ventilation. Owing to the lack of positive pressure ventilators, this was undertaken by students who contributed 167,000 h of hand ventilation. The mortality decreased to 25%. Anesthetists, having special experience with ventilation, became the leaders in the field as Intensive Care developed.
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