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Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
Published on: November 25, 2025
To 'gram or not'? Indications for intraoperative cholangiogram
Lawrence E Tabone1, Sharfi Sarker, Piero M Fisichella
1Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA.
This study looked at how often surgeons use intraoperative cholangiogram (IOC) during laparoscopic cholecystectomy (LC) and whether it helps detect bile duct stones. Over 1,300 patients had LC, and 20% had an IOC. IOC found stones in 13.5% of these cases, but only 17% of those had stones cleared during surgery. Most needed a follow-up ERCP. Preoperative imaging missed stones in many cases. Surgeons used IOC more when liver tests were abnormal or the bile duct was enlarged. The authors suggest IOC is most useful when preoperative tests are unclear and should be used selectively. ERCP remains a key tool for managing stones missed during surgery.
Area of Science:
- Surgical outcomes research in gastrointestinal surgery
- Diagnostic imaging techniques in hepatobiliary medicine
Background:
Current guidelines on intraoperative cholangiogram (IOC) use remain unclear. Surgeons face uncertainty about which patients benefit most from IOC during laparoscopic cholecystectomy. Prior research has shown that IOC can detect bile duct stones, but its routine use is debated. No prior work had resolved how often IOC findings change postoperative management. Existing evidence suggests preoperative imaging may miss bile duct stones. That uncertainty drove this study to analyze practice patterns and outcomes. This gap motivated a retrospective analysis of over 1,300 laparoscopic cholecystectomy cases. No prior work had resolved the effectiveness of IOC in preventing retained stones.
Purpose Of The Study:
This study aimed to assess the role of intraoperative cholangiogram during laparoscopic cholecystectomy. Researchers sought to determine how often IOC is used and when it changes patient care. The specific problem was to evaluate whether IOC improves detection of bile duct stones. Surgeons often debate whether IOC is necessary in all cases. The motivation was to clarify if IOC leads to better outcomes than preoperative imaging. The study focused on how often IOC findings differ from preoperative tests. It also aimed to identify which patient characteristics predict IOC utility. No prior work had resolved the impact of IOC on postoperative ERCP rates.
Main Methods:
The study used a retrospective chart review of patients who had laparoscopic cholecystectomy. Data collection spanned five years, from 2005 to 2009, covering 1,308 procedures. Surgeons involved in the study ranged from 1 to 23, with no specific training reported. Preoperative data included imaging and lab results, such as ultrasound and HIDA scans. Intraoperative decisions about IOC were based on surgeon judgment and patient factors. Postoperative outcomes tracked whether ERCP was needed for retained stones. Statistical analysis compared IOC and non-IOC groups for stone detection rates. No prior work had resolved the impact of surgeon experience on IOC use.
Main Results:
Of 1,308 laparoscopic cholecystectomies, 266 (20%) had an IOC performed. IOC detected bile duct stones in 36 patients (13.5% of IOC cases). Only six of these had stones cleared during surgery, with 30 requiring postoperative ERCP. Among the 1,042 cases without IOC, 31 (3%) had retained stones managed by ERCP. Preoperative imaging failed to detect stones in 26 of the 36 IOC-positive cases. Abnormal liver tests and dilated bile ducts were top IOC indications. Surgeons used IOC more often when preoperative imaging was inconclusive. No prior work had resolved the effectiveness of IOC in preventing ERCP.
Conclusions:
The authors suggest that IOC is most useful when preoperative imaging is inconclusive. They propose that IOC helps identify bile duct stones missed by other tests. The data indicates that IOC findings often lead to postoperative ERCP. The study suggests that IOC use is selective and not routine. The authors propose that preoperative bile duct size aids in IOC decision-making. They suggest that ERCP remains effective for stones missed during surgery. The findings suggest that IOC does not always prevent the need for ERCP. The authors propose that IOC should be used selectively based on patient factors.
Frequently Asked Questions
The main outcome is detecting bile duct stones missed by preoperative imaging in 13.5% of cases.
Only 6 out of 36 cases with IOC-detected stones had successful removal during surgery.
Preoperative imaging failed to detect stones in 26 of 36 IOC-positive cases.
ERCP was used to manage retained stones in 30 of 36 IOC-positive cases and 31 non-IOC cases.
Abnormal liver tests, dilated bile ducts, and gallstone pancreatitis were top indications.
The authors propose IOC should be used selectively based on preoperative imaging and test results.
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