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Updated: May 28, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Primary and isolated adult T-cell leukemia/lymphoma of the bone marrow
Tohru Takahashi1, Hiroyuki Tsukuda, Hideto Itoh
1Department of Hematology and Gastroenterology, Tenshi Hospital, Japan. tohrut@cocoa.ocn.ne.jp
Abstract:
The distribution of adult T-cell leukemia/lymphoma (ATLL) is typically systemic. In addition to peripheral blood (PB) and lymph nodes, extranodal sites such as the skin, lung, liver, gastrointestinal tract, and central nervous system are frequently involved. We report a unique case of ATLL in which the patient presented with prolonged fever. A 65-year-old man had high-grade fever lasting for 2 weeks. He showed no lymphadenopathy, hepatosplenomegaly, skin lesions, or PB involvement. Bone marrow examination showed widespread infiltration of ATLL cells. (18)F-fluorodeoxy glucose positron emission tomography (FDG-PET) revealed that the disease was confined to the bone marrow.
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