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Risk factors associated with biliary pancreatitis in children

Michael H Ma1, Harrison X Bai, Alexander J Park

  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.

Journal of Pediatric Gastroenterology and Nutrition
|October 18, 2011
PubMed

Insights

Hispanic children have a higher risk of biliary pancreatitis. Obesity helps distinguish gallstone from sludge causes, while aspartate aminotransferase indicates biliary pancreatitis in children.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Pancreatology

Background:

  • Biliary pancreatitis in children is not well understood.
  • Risk factors and distinguishing features require further characterization.

Purpose of the Study:

  • To identify risk factors for pediatric biliary pancreatitis.
  • To compare biliary with nonbiliary pancreatitis cases.
  • To differentiate gallstone- from sludge-induced pancreatitis.

Main Methods:

  • Retrospective analysis of 76 pediatric biliary pancreatitis cases from 271 acute pancreatitis cases (1994-2007).
  • Comparison of demographic, clinical, and laboratory data between biliary and nonbiliary pancreatitis.
  • Logistic regression analysis to identify predictors.

Main Results:

  • Gallstones (55%), sludge (21%), and structural defects (24%) were identified causes.
  • Hispanic children showed significantly higher odds for biliary pancreatitis.
  • Elevated aspartate aminotransferase was an independent predictor of biliary pancreatitis.
  • Obesity was more prevalent in gallstone-induced cases compared to sludge-induced cases.

Conclusions:

  • Hispanic ethnicity is a significant risk factor for pediatric biliary pancreatitis.
  • Aspartate aminotransferase serves as a potential biomarker.
  • Obesity can help differentiate gallstone from sludge etiology, guiding management.
Abstract

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