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Executive function following child stroke: the impact of lesion size

Brian Long1, Vicki Anderson, Rani Jacobs

  • 1Murdoch Childrens Research Institute, Melbourne, Australia.

Developmental Neuropsychology
|October 19, 2011
PubMed

Insights

Childhood stroke significantly impacts executive function (EF) in children, affecting cognitive and behavioral skills. Larger brain lesion size, over 25% of brain volume, results in more severe EF deficits.

Area of Science:

  • Pediatric Neurology
  • Neuropsychology
  • Developmental Neuroscience

Background:

  • Childhood stroke is a significant cause of pediatric morbidity and mortality.
  • Neurobehavioral outcomes, particularly executive function (EF), are not well understood.
  • EF is crucial for adaptive behavior and may be vulnerable to early brain injury.

Purpose of the Study:

  • To investigate the impact of childhood stroke on executive function (EF).
  • To determine the relationship between lesion size and EF deficits in children post-stroke.

Main Methods:

  • Recruited 28 children with stroke diagnosed at least 12 months prior to assessment.
  • Conducted neurobehavioral assessments focusing on cognitive and behavioral aspects of EF.
  • Quantified lesion volume using magnetic resonance imaging (MRI) scans.

Main Results:

  • Children with stroke exhibited deficits in cognitive EF, including attention, cognitive flexibility, and information processing.
  • Behavioral EF deficits were prominent, affecting a broad range of behaviors.
  • Lesion size significantly impacted EF outcomes, with larger lesions (>25% brain volume) causing the most detriment.

Conclusions:

  • Childhood stroke leads to significant cognitive and behavioral executive function impairments.
  • Lesion volume is a critical factor influencing the severity of executive function deficits after childhood stroke.
  • Further research is needed to understand long-term neurobehavioral sequelae and inform interventions.

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