Essential and supporting host cell factors for HIV-1 budding
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Updated: May 28, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
Published on: June 26, 2019
Aurelien Dordor1, Emilie Poudevigne, Heinrich Göttlinger
1Unit of Virus Host Cell Interactions UMI 3265 Université Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France.
Abstract:
HIV-1 employs its structural proteins to orchestrate assembly and budding at the plasma membrane of host cells. The Gag polyprotein is sufficient to form virus-like particles in the absence of other viral proteins and provides a platform to interact with numerous cellular factors that regulate Gag trafficking to the site of assembly and budding. Notably endosomal sorting complexes required for transport have attained much attention over the last decade because of their essential role in virion release. Here we review recent advances in understanding the role of host cell factors recruited by Gag during HIV-1 assembly and budding.
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