Related Experiment Video
Updated: May 28, 2026

Micropatterning and Assembly of 3D Microvessels
Published on: September 9, 2016
The adventitia: a progenitor cell niche for the vessel wall
Mark W Majesky1, Xiu Rong Dong, Virginia Hoglund
1Seattle Children's Research Institute, University of Washington, Seattle, Wash., USA. mwm84@uw.edu
Abstract:
Recent observations suggest that the adventitial layer of blood vessels exhibits properties resembling a stem/progenitor cell niche. Progenitor cells have been isolated from the adventitia of both murine and human blood vessels with the potential to form endothelial cells, mural cells, osteogenic cells, and adipocytes. These progenitors appear to cluster at or near the border zone between the outer media and inner adventitia. In the mouse, this border zone region corresponds to a localized site of sonic hedgehog signaling in the artery wall. This brief review will discuss the emerging evidence that the tunica adventitia may provide a niche-like signaling environment for resident progenitor cells and will address the role of the adventitia in growth, remodeling, and repair of the artery wall.
More Related Videos
10:57Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
Published on: September 12, 2017
05:41Using a Cell-Tracer Injection to Investigate the Origin of Neointima-Forming Cells in a Rat Saccular Side Wall Model
Published on: March 16, 2022
Related Concept Videos
Overview of the Vascular System
Mechanism of Angiogenesis
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Angiogenesis and Blood Supply
Structure of Blood Vessels
Stem Cell Niche