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Updated: May 28, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Effect of usnic acid on Candida orthopsilosis and C. parapsilosis
Regina Helena Pires1, Rodrigo Lucarini, Maria Jose Soares Mendes-Giannini
1Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil. rehepi@gmail.com
Abstract:
The activity of usnic acid against Candida orthopsilosis and Candida parapsilosis on planktonic and biofilm conditions was investigated by using a broth microdilution and microplate methods. Potent in vitro activities against different Candida species were obtained. The metabolic activity of sessile cells of C. parapsilosis complex was reduced by 80% at four times the 80% inhibitory concentration. The in vitro studies support further efforts to determine whether usnic acid can be used clinically to cure patients with Candida infections.
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