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Published on: January 10, 2017
A novel fluorescent aptasensor based on single-walled carbon nanohorns
Shuyun Zhu1, Shuang Han, Ling Zhang
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Nanoscale
|October 19, 2011
Summary
Single-walled carbon nanohorns were utilized to create a novel aptasensor for detecting thrombin. This biosensor demonstrates high sensitivity and selectivity, with a low detection limit of 100 pM.
Area of Science:
- Nanomaterials Science
- Biosensor Technology
- Analytical Chemistry
Background:
- Thrombin is a critical biomarker in hemostasis and thrombosis.
- Development of sensitive and selective detection methods for thrombin is essential for clinical diagnostics.
- Existing detection methods often face limitations in sensitivity, selectivity, or complexity.
Purpose of the Study:
- To develop a novel aptasensor for highly sensitive and selective thrombin detection.
- To explore the application of single-walled carbon nanohorns (SWCNHs) in aptasensor construction for the first time.
- To evaluate the analytical performance of the SWCNH-based aptasensor.
Main Methods:
- Synthesis and characterization of single-walled carbon nanohorns (SWCNHs).
- Immobilization of thrombin-binding aptamers onto the SWCNH platform.
- Fabrication and optimization of the aptasensor.
- Electrochemical or optical detection of thrombin binding to the aptasensor.
Main Results:
- Successful construction of a novel aptasensor using SWCNHs.
- The aptasensor exhibited high sensitivity and excellent selectivity for thrombin detection.
- Achieved a low detection limit for thrombin as low as 100 pM.
- Demonstrated good stability and reproducibility of the aptasensor.
Conclusions:
- Single-walled carbon nanohorns are effective nanomaterials for constructing high-performance aptasensors.
- The developed aptasensor offers a promising tool for sensitive and selective thrombin detection.
- This work opens new avenues for utilizing SWCNHs in advanced biosensing applications.
