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Updated: May 28, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

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Published on: September 18, 2013

Challenges associated with tyrosine kinase inhibitor therapy for metastatic thyroid cancer

Maria E Cabanillas1, Mimi I Hu, Jean-Bernard Durand

  • 1Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Journal of Thyroid Research
|October 19, 2011
PubMed

Insights

Tyrosine kinase inhibitors (TKIs) offer promising treatments for advanced thyroid cancers by targeting angiogenesis. Understanding and managing their adverse events is crucial for effective long-term therapy.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic medullary and differentiated thyroid cancers are treated with tyrosine kinase inhibitors (TKIs) targeting angiogenesis.
  • Commercially available TKIs include sorafenib, sunitinib, and pazopanib.
  • Vandetanib is US-approved for medullary thyroid cancer.

Purpose of the Study:

  • To review the adverse event profiles of TKIs used in thyroid cancer.
  • To discuss the management of common toxicities associated with these therapies.
  • To address challenging situations encountered during chronic TKI treatment for thyroid cancer.

Main Methods:

  • Literature review of clinical studies and drug approvals.
  • Analysis of adverse event data from published trials.
  • Clinical experience in managing TKI-related toxicities.

Main Results:

  • TKIs targeting angiogenesis are effective for metastatic thyroid cancers.
  • Common toxicities require careful monitoring and management.
  • Adherence to therapy depends on managing adverse events.

Conclusions:

  • TKIs represent a significant therapeutic advance for advanced thyroid cancers.
  • Proactive management of TKI-induced toxicities is essential for patient benefit.
  • Understanding and mitigating adverse events optimizes chronic TKI therapy in thyroid cancer.

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