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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
An MRI-compatible robotic system with hybrid tracking for MRI-guided prostate intervention
Axel Krieger1, Iulian I Iordachita, Peter Guion
1Department ofMechanical Engineering and the Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD 21218, USA. krieger.axel@gmail.com
IEEE Transactions on Bio-Medical Engineering
|October 20, 2011
Summary
The Access to Prostate Tissue (APT) II system offers MRI-guided prostate interventions with a novel tracking method. This scanner-independent system demonstrates favorable targeting accuracy in phantom and human trials.
Area of Science:
- Medical Imaging
- Surgical Technology
- Prostate Interventions
Background:
- Transrectal prostate interventions require precise targeting under Magnetic Resonance Imaging (MRI) guidance.
- Existing systems often rely on specific MRI scanner interfaces or complex tracking methods.
- There is a need for versatile and accurate systems for minimally invasive prostate procedures.
Purpose of the Study:
- To report the development and clinical evaluation of the Access to Prostate Tissue (APT) II system.
- To assess the targeting accuracy and usability of the APT II system for MRI-guided transrectal prostate interventions.
- To demonstrate the scanner-independent nature and portability of the APT II system.
Main Methods:
- Development of a scanner-independent system with novel manipulator mechanics and a steerable needle channel.
- Implementation of a six degree-of-freedom hybrid tracking method combining passive fiducial tracking and incremental motion measurements.
- Evaluation in prostate phantom experiments and two clinical human-subject procedures using standard MRI sequences.
Main Results:
- The APT II system achieved favorable targeting accuracy compared to existing passive and active tracking systems.
- The system demonstrated successful application in MRI-guided transrectal prostate interventions.
- The portable design and minimal custom scanner interfacing facilitate use across different MRI scanners.
Conclusions:
- The APT II system represents a significant advancement in MRI-guided transrectal prostate interventions.
- Its novel tracking and design offer improved accuracy, versatility, and ease of use.
- The system is well-suited for broader clinical adoption in prostate interventions.

