Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping of validated apathy scales onto the apathy diagnostic criteria for neurocognitive disorders.

International psychogeriatrics·2025
Same author

Elimination of Interface Energy Barriers Using Dendrimer Polyelectrolytes with Fractal Geometry.

ACS applied materials & interfaces·2023
Same author

Dual Task Performance Is Associated with Amyloidosis in Cognitively Healthy Adults.

The journal of prevention of Alzheimer's disease·2022
Same author

Recruitment into the Alzheimer Prevention Trials (APT) Webstudy for a Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD).

The journal of prevention of Alzheimer's disease·2020
Same author

TRC-PAD: Accelerating Recruitment of AD Clinical Trials through Innovative Information Technology.

The journal of prevention of Alzheimer's disease·2020
Same author

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD): Experience from the First 3 Years.

The journal of prevention of Alzheimer's disease·2020
Same journal

Reduced diffusion associated with amyloid-related imaging abnormalities in three patients treated with donanemab.

Neurocase·2026
Same journal

A rare homozygous mutation in <i>TYROBP</i> resulting in early-onset dementia with bone cysts.

Neurocase·2026
Same journal

Evaluating language lateralization after recurrent malignant glioma: a longitudinal functional MRI and voxel-based morphometry case study.

Neurocase·2026
Same journal

The anatomy of concealed awareness: lessons from partial locked-in syndrome.

Neurocase·2026
Same journal

A case report of crossed aphasia, grasping, and intermanual conflict with the left hand.

Neurocase·2026
Same journal

Bimanual asymmetric exercises reduce pathological mirror movements after stroke: a case report with disconnectome mapping.

Neurocase·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Posterior cortical atrophy: Unique features.

T Tom1, J L Cummings, J Pollak

  • 1a Department of Neurology , Los Angeles , CA , 90095-1769 , USA.

Neurocase
|October 21, 2011
PubMed
Summary
This summary is machine-generated.

Posterior cortical atrophy (PCA) associated with Alzheimer's disease (AD) presents with diverse visual-cognitive symptoms. This case highlights unique occipital subcortical gliosis in AD-related PCA, confirmed by comprehensive findings.

More Related Videos

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Related Experiment Videos

Last Updated: May 28, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Area of Science:

  • Neurology
  • Pathology

Background:

  • Posterior cortical atrophy (PCA) is a syndrome impacting visual and cognitive functions.
  • PCA can be caused by Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), or subcortical gliosis.

Purpose of the Study:

  • To report a unique case of PCA with comprehensive documentation.
  • To detail the clinical, radiologic, electroencephalographic, metabolic, and histopathologic findings.
  • To establish the presence of occipital subcortical gliosis in an AD patient with PCA.

Main Methods:

  • Comprehensive clinical assessment and laboratory testing.
  • Radiological imaging including MRI and PET scans.
  • Electroencephalography (EEG) and histopathological examination (autopsy).

Main Results:

  • The patient exhibited various PCA manifestations attributed to AD, including visual agnosia, cortical blindness, and cognitive deficits.
  • Imaging and EEG confirmed PCA features.
  • Histopathology revealed unique occipital subcortical gliosis in the context of AD.

Conclusions:

  • PCA due to AD can manifest with a wide spectrum of neurological and cognitive symptoms.
  • Detailed multimodal assessment is crucial for diagnosing PCA and its underlying cause.
  • Occipital subcortical gliosis represents a distinct pathological finding in some cases of AD-related PCA.