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Updated: May 28, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
Aécio Flávio Meirelles de Souza1, Fábio Heleno de Lima Pace, Júlio Maria Fonseca Chebli
1Hepatology Reference Center, Gastroenterology Department, Universidade Federal de Juiz de Fora, Rua Albino Martins Ribeiro 324, Juiz de Fora, Minas Gerais, Brazil. aecio.meirelles@gmail.com
Objectives:
To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings.
Subjects And Methods:
Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance.
Results:
IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR.
Conclusions:
Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.
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