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08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Scleroderma digital ulcers complicated by infection with fecal pathogens
Dilia Giuggioli1, Andreina Manfredi, Michele Colaci
1University of Modena and Reggio Emilia, Modena, Italy. giuggioli.dilia@policlinico.mo.it
Arthritis Care & Research
|October 21, 2011
Summary
Digital ulcers in systemic sclerosis (SSc) can be complicated by infections. This study found fecal pathogens like E. coli in 26% of SSc patients with infected digital ulcers, highlighting the need for improved patient hygiene.
Area of Science:
- Microbiology
- Dermatology
- Rheumatology
Background:
- Digital ulcers are a common and painful complication of systemic sclerosis (SSc), often leading to significant disability.
- Infectious complications can worsen SSc skin lesions, with bacteria from endogenous flora being potential culprits.
Purpose of the Study:
- To investigate the potential involvement of fecal pathogens in the development of digital ulcers in patients with systemic sclerosis.
Main Methods:
- A retrospective analysis of 42 systemic sclerosis patients with digital ulcers and signs of local bacterial infection.
- Microbiologic examinations were performed on all suspected infected digital ulcers.
Main Results:
- Bacterial infection was confirmed in all 42 patients; Staphylococcus aureus was the most common (50%).
- Intestinal bacteria were found in 26% of patients: Escherichia coli (7 patients) and Enterococcus faecalis (4 patients).
- Diffuse cutaneous SSc was more prevalent in the subgroup with fecal pathogen infections (Fisher's P = 0.011).
Conclusions:
- Effective management of SSc digital ulcers requires attention to infectious complications.
- The significant prevalence of fecal pathogens suggests self-care limitations and inadequate hand hygiene contribute to infections.
- Mandatory education on hand hygiene for patients and caregivers is crucial to prevent these complications.
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