Significant correlation between left ventricular systolic and diastolic dysfunction and decreased glomerular filtration rate

Area of Science:

• Nephrology
• Cardiology
• Internal Medicine

Background:

• Cardiac dysfunction is a significant predictor of poor outcomes in patients with renal failure.
• Functional cardiac abnormalities are commonly observed in individuals with renal insufficiency.

Purpose of the Study:

• To investigate the relationship between left ventricular systolic and diastolic function and renal function across varying degrees of kidney function.
• To identify clinical and echocardiographic factors associated with impaired cardiac function in patients with renal disease.

Main Methods:

• A cross-sectional study involving 167 outpatients with diverse renal function.
• Echocardiography was utilized to assess left ventricular systolic and diastolic functions.
• Multivariate analysis was performed to determine associations between cardiac parameters and renal function.

Main Results:

• A prevalence of 31.7% for left ventricular ejection fraction (LVEF) <50% was observed.
• Low estimated glomerular filtration rate (eGFR) was significantly associated with LVEF <50% (odds ratio = 0.957; p = 0.004).
• Decreased eGFR and elevated uric acid levels were associated with higher E/Ea ratios, indicating diastolic dysfunction.

Conclusions:

• There is a significant correlation between reduced left ventricular ejection fraction (<50%) and impaired diastolic function (high E/Ea) with decreased estimated glomerular filtration rate.
• These findings underscore the interdependence of cardiac and renal health, emphasizing the need for integrated management strategies.