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Advances in imaging in Parkinson's disease
A Jon Stoessl1, Wr Wayne Martin, Martin J McKeown
1Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, BC, Canada. jstoessl@mail.ubc.ca
The Lancet. Neurology
|October 22, 2011
Summary
Advanced imaging techniques can detect Parkinson's disease changes, aiding diagnosis and tracking progression. These methods offer insights into treatment complications and the dopamine system, and are valuable for animal model research.
Area of Science:
- Neuroimaging
- Neurology
- Biomarker Discovery
Background:
- Imaging advances enable detection of functional and structural changes in Parkinson's disease (PD).
- Current diagnostic use of imaging in PD is limited but evolving.
- Imaging offers potential as a biomarker for early PD detection and progression monitoring.
Purpose of the Study:
- To explore the evolving role of neuroimaging in Parkinson's disease.
- To highlight imaging's utility in detecting premotor PD and disease progression.
- To discuss imaging applications in understanding PD complications, treatment effects, and dopamine's role.
Main Methods:
- Review of current and emerging neuroimaging techniques applicable to Parkinson's disease.
- Analysis of imaging data for diagnostic and prognostic applications.
- Consideration of imaging in preclinical and animal models of PD.
Main Results:
- Neuroimaging can identify subtle functional and structural alterations in PD.
- Imaging shows promise as a biomarker for early disease detection and tracking progression.
- Techniques provide insights into dopamine system dysfunction and treatment-related complications.
Conclusions:
- Neuroimaging is increasingly vital for Parkinson's disease research and clinical applications.
- Imaging's role extends beyond diagnosis to early detection, progression monitoring, and therapeutic research.
- Application in animal models facilitates the study of disease mechanisms and novel therapies.
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