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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: May 28, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Iatrogenic immunosuppression and cutaneous malignancy.

Jennifer L DePry1, Kurtis B Reed, Robert H Cook-Norris

  • 1Kansas City University of Medicine and Biosciences, 1750 Independence Ave, Kansas City, MO 64106, USA.

Clinics in Dermatology
|October 22, 2011
PubMed
Summary
This summary is machine-generated.

Patients on long-term immunosuppressive therapy for autoimmune diseases or after transplants face a higher risk of developing skin cancers. This includes common types like squamous cell carcinoma, basal cell carcinoma, and malignant melanoma.

Related Experiment Videos

Last Updated: May 28, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Area of Science:

  • Immunology
  • Dermatology
  • Oncology

Background:

  • Patients with autoimmune and inflammatory conditions often require long-term immunosuppressive therapy.
  • Significant patient populations undergoing immunosuppression include those with rheumatoid arthritis, psoriasis, and solid-organ transplants.
  • Iatrogenic immunosuppression, while improving disease outcomes, is linked to increased risks.

Purpose of the Study:

  • To highlight the increased risk of skin cancer in patients undergoing immunosuppressive therapy.
  • To identify specific types of skin cancer associated with immunosuppression.
  • To inform healthcare providers about potential risks in managing immunosuppressed patients.

Main Methods:

  • This is a summary of existing research and clinical observations.
  • Analysis of patient populations with autoimmune diseases and transplant recipients.
  • Review of epidemiological data on skin cancer incidence in immunosuppressed individuals.

Main Results:

  • Immunosuppression is associated with a significantly elevated risk of developing skin cancer.
  • Common skin cancers observed include squamous cell carcinoma, basal cell carcinoma, and malignant melanoma.
  • The risk is present in various patient groups receiving immunosuppressive treatments.

Conclusions:

  • Long-term immunosuppressive therapy necessitates vigilant monitoring for skin cancer development.
  • Awareness of this risk is crucial for early detection and management in affected patients.
  • Further research may explore specific risk factors and preventative strategies.