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Updated: May 28, 2026
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
[Preparation and in vitro characterization of apigemin-loaded nanostructured lipid carriers]
Ying-jie Zhai1, Chen-yu Guo, Jin-ning Hou
1College of Pharmacy, Shandong University, Jinan 250012, China. zhaiyingjiemp5@163.com
Objective:
To prepare Apigemin-loaded nanostructured lipid carriers (Api-NLCs) and evaluate their characteristics.
Methods:
Api-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature. The physicochemical properties such as morphology, size distribution, zeta potential, entrapment efficiency, drug loading and drug release in vitro were evaluated.
Results:
The obtained nanoparticles were spherical under transmission electron microscope. The mean diameter was 212.1 nm, the zeta potential was - 14.65 mV, the mean entrapment efficiency was 82.4% and the mean drug loading was 0.97%. The total drug release was 30% in 2 hours followed by a slow and sustained release in vitro.
Conclusion:
The optimal Api-NLCs show stable characteristics and broad prospects for application.
