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Updated: May 28, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and
Cong Li1, Chang-he Wang, Ai-guo Zeng
1School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. lcxjtu.2009@stu.xjtu.edu.cn
Objective:
To study the supermolecular interaction between different concentrations of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and imperatorin (IM) and isoimperatorin (ISO) using phase solubility analysis.
Methods:
Different concentrations of hydroxypropyl-beta-cyclodextrin were prepared, added overdose of imperatorin or isoimperatorin, made a phase solubility diagram.
Results:
The relationship of phase solubility was approximatively linear and the model of inclusion compound was AL and the inclusion ratio of IM, ISO versus HP-beta-CD was 1: 1. The inclusion constants were 214.4, 587.2 L/mol respectively.
Conclusions:
Supermolecular inclusion of HP-beta-CD of imperatorin/isoimperatorin could evidently increase the solubility of imperatorin and isoimperatorin, the enhancing effect of isoimperatorin solubility is better than that of imperatorin.
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