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[Optimization of the matrix formulation of compound Die Da Zhen Tong cataplasm by uniform design]
Ji-xing Zhang1, Jian-ping Wang, Feng Zhu
1Guangdong Pharmaceutical University, Guangzhou 510006, China. jxzh1998282@yahoo.com.cn
Objective:
To optimize the matrix formulation of compound Die Da Zhen Tong cataplasm.
Methods:
The optimal preparation was selected by U17 (17(16)) uniform design, independent variables were the percentage ratio of the matrix formulation component part in compound Die Da Zhen Tong cataplasm,and the viscosity, continued viscosity and overall desirability used as indexes were dependent variables.
Results:
The percentage of the matrix formulation component part in compound Die Da Zhen Tong cataplasm was, NP-700: carbomer 980: PVP K-90: dihydroxy aluminum: tartaric: kaolinite: sorbitol: glycerin = 5: 1. 2: 2.5: 0.25: 0.15:4: 12: 5.
Conclusion:
The optimized cataplasm has good viscosity, continued viscosity and high overall desirability.
