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Diagnostic criteria for corticobasal syndrome: a comparative study
Robert Mathew1, Thomas H Bak, John R Hodges
1Neurosciences Research Australia, and University of New South Wales, Sydney, Australia.
Journal of Neurology, Neurosurgery, and Psychiatry
|October 25, 2011
Summary
The Cambridge criteria are more effective for diagnosing corticobasal syndrome early. Cognitive and language impairments are common from the start of this neurological condition.
Area of Science:
- Neurology
- Neuroscience
- Clinical Diagnostics
Background:
- Corticobasal syndrome lacks established diagnostic criteria.
- Comparison of Toronto, Mayo Clinic, and Cambridge criteria is needed.
Purpose of the Study:
- To compare and apply three sets of criteria for corticobasal syndrome.
- To determine the applicability of criteria at different disease stages.
Main Methods:
- Compared three diagnostic criteria for corticobasal syndrome.
- Applied criteria to 40 patients with focal cortical syndrome (apraxia, Parkinsonism).
Main Results:
- Cognitive and speech/language impairments were prevalent from presentation.
- Cambridge criteria identified a higher proportion of early-stage cases (73.3%).
- Concordance between the three criteria was poor.
Conclusions:
- Cognitive and language deficits are early indicators of corticobasal syndrome.
- Cambridge criteria are more suitable for early diagnosis.
- A modification to include aphasia is suggested.
