Related Experiment Video
Updated: May 28, 2026

08:51
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer
Emilie Bertrand1, Cristine Gonçalves, Ludivine Billiet
1Laboratoire LAMBE équipe MPI, UMR 8587, Université d'Evry Val d'Essonne, Evry, France.
Abstract:
A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

