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Related Experiment Videos

Anxiety and the gastrointestinal system.

M D Fossey1, R B Lydiard

  • 1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston.

Psychiatric Medicine
|January 1, 1990
PubMed
Summary

Anxiety and gastrointestinal (GI) issues are linked, with high anxiety prevalence in functional GI disorders suggesting shared brain-gut pathways. Medications for anxiety may help treat these GI conditions.

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Area of Science:

  • Neurogastroenterology
  • Psychiatry
  • Gastroenterology

Background:

  • Growing evidence links anxiety and gastrointestinal (GI) function.
  • Functional GI disorders (FGIDs) show high rates of anxiety and depression.
  • Brain-gut axis research highlights the connection between the central nervous system (CNS) and the GI tract.

Purpose of the Study:

  • To explore the common or interacting pathophysiology between anxiety and FGIDs.
  • To investigate the role of the enteric nervous system (ENS) and CNS similarities in this association.
  • To assess the potential of anxiety medications for treating FGIDs.

Main Methods:

  • Review of studies on stress and GI function.
  • Analysis of psychopathology in FGID patients.
  • Examination of neurobiological links between the brain and GI tract.

Main Results:

  • High prevalence of anxiety disorders in FGID patients is consistently observed.
  • The brain-gut axis and ENS-CNS similarities offer plausible explanations for the comorbidity.
  • Anxiolytics and antidepressants show potential therapeutic value.

Conclusions:

  • The brain-gut axis and shared pathophysiology likely contribute to the high comorbidity of anxiety and FGIDs.
  • Anxiety-targeting medications may be beneficial for FGID treatment, particularly refractory cases.
  • Further clinical studies are required to validate treatment efficacy.

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