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Prevention of post liver transplant HBV recurrence

Geoffrey W McCaughan¹

¹The AW Morrow Gastroenterology and Liver Centre, The Centenary Research Institute, Royal Prince Alfred Hospital and The University of Sydney, Missenden Road, Camperdown, NSW, 2050, Australia. g.mccaughan@centenary.usyd.edu.au.

Hepatology International

|October 25, 2011

Abstract

Background:

Twenty years ago, liver transplantation for hepatitis B had been a relative contraindication to universal HBV recurrence and poor outcomes. Over the ensuing two decades, there has been refinement of prevention strategies in order to minimize HBV recurrence in the allograft.

Results:

Currently, the most efficacious and cost-effective strategies include newer oral antiviral drugs in combination with low doses of hepatitis B immunoglobulin (HBIG). More recently, strategies have been successful in withdrawing HBIG and newer approaches of HBIG avoidance are currently under development.

Conclusion:

Thus, 20 years afterward, HBV recurrence is <5% and outcomes following liver transplantation are excellent.

Keywords:

Adefovir Entecavir HBIG HBV recurrence Lamivudine Liver transplantation Tenofovir

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