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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Thyroid infiltrating dendritic cells, epitheloid cells and giant cells in iodine deficiency
P Dimal1, M Wilders-Truschnig, G Leb
1Department of Internal Medicine, School of Medicine, Karl Franzens University Graz, Austria.
Abstract:
This study describes dendritic cells in thyroid sections of iodine deficient goiters. Cells were characterized by monoclonal markers and detected by immunohistochemistry and double labelling immunofluorescence. We observed dendritic cells located in focal aggregates in the interstitium and epitheloid cells as well as multinucleated giant cells filling thyroid follicles. All these cells showed strong positivity for the MHC class II molecules HLA-DR, -DQ, -DP and RFD1, a monoclonal marker for active antigen presenting cells.
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