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Penile pyoderma gangrenosum successfully treated with topical Imiquimod
Santosh P Rathod1, Bela B Padhiar, Umesh K Karia
1Deparment of Skin and V.D., B.J. Medical College, Civil Hospital, Ahmedabad, Gujarat, India.
Indian Journal of Sexually Transmitted Diseases and AIDS
|October 25, 2011
Summary
Topical Imiquimod 5% cream successfully treated a rare case of penile pyoderma gangrenosum (PG) in an HIV-positive patient. This treatment led to complete lesion clearance and sustained remission, offering a new therapeutic option.
Area of Science:
- Dermatology
- Immunology
- Infectious Diseases
Background:
- Pyoderma gangrenosum (PG) is a rare, ulcerative, inflammatory neutrophilic dermatosis.
- Genital involvement in PG is exceptionally uncommon, posing diagnostic and therapeutic challenges.
Observation:
- A 24-year-old male living with HIV/AIDS presented with progressive, non-responsive genital ulceration over 15-18 months.
- Biopsies revealed acute-on-chronic inflammation; lesions showed partial response to corticosteroids but relapsed upon dose reduction.
Findings:
- Topical Imiquimod 5% cream applied daily for 2-4 weeks resulted in complete resolution of penile PG lesions.
- The patient has remained in remission for six months post-treatment.
Implications:
- Topical Imiquimod 5% cream represents a promising and effective treatment for penile pyoderma gangrenosum, particularly in immunocompromised individuals.
- This case expands treatment options for rare dermatological conditions affecting sensitive anatomical sites.
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