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Heart type fatty acid binding protein in relation to pharmacologic scintigraphy in coronary artery disease

Eftihia Sbarouni1, Panagiota Georgiadou, Maria Koutelou

  • 12 nd Department of Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, 17674 Athens, Greece. esbarouni@yahoo.gr

Clinical Chemistry and Laboratory Medicine
|October 26, 2011
PubMed

Insights

Serum levels of heart-type fatty acid-binding protein (H-FABP) do not change during adenosine stress testing in patients with coronary artery disease, regardless of inducible ischemia.

Area of Science:

  • Cardiology
  • Biomarkers
  • Ischemia

Background:

  • Heart-type fatty acid-binding protein (H-FABP) is a known marker for myocardial necrosis.
  • The role of H-FABP during myocardial ischemia, particularly during stress testing, remains unclear.

Purpose of the Study:

  • To investigate changes in serum H-FABP levels during adenosine stress testing in patients with stable coronary artery disease (CAD).
  • To determine if H-FABP levels differ based on the presence or absence of inducible ischemia.

Main Methods:

  • Study included 30 patients with stable CAD undergoing adenosine stress testing and nuclear imaging.
  • Serum samples were collected before stress, immediately after adenosine infusion, and 1, 2, and 3 hours post-infusion.

Main Results:

  • No significant differences in H-FABP serum levels were observed across the five sampling time points in the overall patient group (p=0.99).
  • H-FABP levels showed no significant variation between patients with positive (p=1) or negative (p=0.98) stress test results.

Conclusions:

  • Serum H-FABP levels do not significantly change during pharmacologic stress testing in patients with known CAD.
  • The presence or absence of inducible ischemia does not impact H-FABP levels during this type of stress test.
Abstract

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