Related Experiment Video
Updated: May 28, 2026
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Emerging therapies for osteoporosis
1Orthopedic and Rheumatology Institute, Department of Rheumatology, Center for Osteoporosis and Metabolic Bone Disease, Cleveland, OH, USA. dealc@ccf.org
Rheumatic Diseases Clinics of North America
|October 26, 2011
Summary
This review explores new bone remodeling drugs, focusing on antiresorptive and anabolic agents. Emerging research links serotonin and Wnt signaling to bone health, potentially revolutionizing skeletal therapies.
Area of Science:
- Bone biology and therapeutic development.
- Endocrinology and metabolic bone disease.
- Pharmacology of skeletal agents.
Background:
- Bone remodeling involves complex pathways regulating bone formation and resorption.
- Current therapeutic strategies target specific steps in these pathways.
- Emerging research suggests systemic factors influence skeletal homeostasis.
Purpose of the Study:
- To review the conceptual framework of antiresorptive and anabolic agents.
- To discuss novel therapeutic agents currently in development.
- To highlight recent findings impacting the understanding of bone remodeling.
Main Methods:
- Review of existing literature on bone remodeling pathways.
- Analysis of preclinical and clinical data for novel agents.
- Synthesis of recent research on systemic influences on bone.
Main Results:
- Identification of key molecular targets for therapeutic intervention.
- Discussion of novel antiresorptive and anabolic agents under investigation.
- Exploration of the role of serotonin and Wnt signaling in bone metabolism.
Conclusions:
- New therapeutic agents targeting bone formation and resorption are advancing.
- The interplay between the gut-brain axis, serotonin, and bone remodeling presents a paradigm shift.
- Targeting Wnt signaling pathways offers promising anabolic therapeutic strategies.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...