Post embolization syndrome in doxorubicin eluting chemoembolization with DC bead
Maria Pomoni1, Katerina Malagari, Hippokratis Moschouris
1Evgenidion University Hospital, Greece.
Hepato-Gastroenterology
|October 26, 2011
Summary
Post embolization syndrome (PES) after chemoembolization for hepatocellular carcinoma (HCC) is common but indicates tumor response, not liver damage. Fever and pain correlate with embolization extent and tumor size.
Area of Science:
- Interventional Radiology
- Hepatobiliary Oncology
- Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver malignancy.
- Transarterial chemoembolization (TACE) is a common treatment for HCC.
- Doxorubicin-loaded DC Bead (DEB-DOX) TACE is an established therapeutic approach.
Purpose of the Study:
- To investigate the incidence and characteristics of post embolization syndrome (PES) in HCC patients treated with DEB-DOX.
- To determine the relationship between PES and treatment parameters, tumor response, and liver function.
Main Methods:
- A retrospective study of 237 HCC patients undergoing sequential DEB-TACE.
- Patients received up to 3 sessions of DEB-TACE every two months.
- Doxorubicin-loaded beads (100-500µm) were used for embolization.
Main Results:
- Post embolization syndrome (PES) occurred in up to 86.5% of patients.
- Fever and pain correlated significantly with the extent of embolization and baseline tumor diameter.
- PES was associated with tumor necrosis but not with elevated liver enzymes.
Conclusions:
- Post embolization syndrome (PES) following DEB-DOX treatment in HCC patients is a marker of treatment efficacy and tumor response.
- PES does not indicate collateral damage to healthy liver tissue.
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