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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Selenium and asthma.

Robert L Norton1, Peter R Hoffmann

  • 1Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

Molecular Aspects of Medicine
|October 26, 2011
PubMed
Summary
This summary is machine-generated.

Selenium (Se) is a vital antioxidant. While its role in asthma is complex, research suggests Se supplementation benefits may depend on individual status, impacting immune function.

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Area of Science:

  • Nutritional Immunology
  • Respiratory Medicine
  • Biochemistry

Background:

  • Asthma pathogenesis involves oxidative stress, prompting interest in selenium's antioxidant role.
  • Human studies show inconsistent associations between selenium status and asthma prevalence or severity.
  • This highlights challenges in nutritional epidemiology and asthma's complex etiology.

Purpose of the Study:

  • To review human and animal study findings on selenium intake and asthma.
  • To explore the mechanistic basis of selenium's effects on immune function in asthma.
  • To discuss safe and effective strategies for selenium supplementation in inflammatory conditions.

Main Methods:

  • Review of human observational and intervention studies on selenium and asthma.
  • Analysis of results from mouse models of asthma.
  • Summary of mechanistic studies on selenium's impact on immune cell function.

Main Results:

  • Human studies provide inconclusive evidence on selenium status and asthma.
  • Mouse models suggest selenium supplementation benefits are contingent on baseline selenium levels.
  • Mechanistic studies indicate selenium influences T helper cell differentiation and immune cell function.

Conclusions:

  • The role of selenium in asthma is complex and influenced by individual selenium status.
  • Selenium supplementation requires careful consideration of both potential benefits and adverse effects.
  • Future strategies may optimize selenium's use for asthma and other immune-mediated disorders.