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Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
Published on: January 13, 2023
Cutting edge: Natural helper cells derive from lymphoid progenitors
Qi Yang1, Steven A Saenz, Daniel A Zlotoff
1Department of Pathology, Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Journal of Immunology (Baltimore, Md. : 1950)
|October 26, 2011
Summary
Natural helper (NH) cells, innate immune cells, originate from bone marrow lymphoid progenitors. This discovery expands the known lymphocyte family, including NH cells as a new type of innate lymphocyte.
Area of Science:
- Immunology
- Cell Biology
- Developmental Biology
Background:
- Natural helper (NH) cells are newly identified innate immune cells.
- NH cells play roles in type 2 immunity against helminths and airway hypersensitivity in influenza.
- The developmental origins (ontogeny) of NH cells remain largely unknown.
Purpose of the Study:
- To investigate the developmental origin of Natural helper (NH) cells.
- To determine the progenitor populations that give rise to NH cells.
- To characterize the lineage commitment of NH cells within the immune system.
Main Methods:
- Utilized RAG-1Cre/ROSA26(YFP) reporter mice to trace cell lineage.
- Analyzed the dependence of NH cell development on the Flt3 cytokine receptor.
- Compared the differentiation potential of lymphoid progenitors versus myeloid-erythroid progenitors in vivo.
Main Results:
- NH cells exhibit a history of RAG-1 expression, indicating a lymphoid developmental origin.
- Flt3 signaling is crucial for the efficient generation of bone marrow lymphoid progenitors.
- In vivo studies confirmed that lymphoid progenitors, not myeloid-erythroid progenitors, generate NH cells.
Conclusions:
- Natural helper (NH) cells are a distinct type of innate lymphocyte.
- NH cells arise from bone marrow lymphoid progenitors.
- This study expands the lymphocyte family to include NH cells, highlighting their innate immune function and lymphoid lineage.
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