Bicyclic peptide antagonists derived from genetically encoded combinatorial libraries
Related Experiment Video
Updated: May 28, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
1Ecole Polytechnique Fédérale de Lausanne, EPFL Institute of Chemical Sciences and Engineering, CH1015 Lausanne. christian.heinis@epfl.ch
Abstract:
Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable molecular structures for the development of therapeutics. By using a combinatorial methodology based on phage display and a chemical cyclisation reaction, we are generating bicyclic peptide antagonists of protein targets with therapeutic applications in mind.
More Related Videos
Related Concept Videos
Inhibitors of Gram-positive Cell Wall Synthesis
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

