Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering low-symmetry colloidal crystals with optical anisotropies.

Science advances·2026
Same author

Retraction of "Bisboronic Acids for Selective, Physiologically Relevant Direct Glucose Sensing with Surface-Enhanced Raman Spectroscopy".

Journal of the American Chemical Society·2024
Same author

Discovering polyelemental nanostructures with redistributed plasmonic modes through combinatorial synthesis.

Science advances·2023
Same author

Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors.

Scientific reports·2022
Same author

Bioresorbable Microdroplet Lasers as Injectable Systems for Transient Thermal Sensing and Modulation.

ACS nano·2021
Same author

Plasmon-Driven Chemistry in Ferri-/Ferrocyanide Gold Nanoparticle Oligomers: A SERS Study.

Journal of the American Chemical Society·2020

Related Experiment Video

Updated: May 28, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Advances in localized surface plasmon resonance spectroscopy biosensing.

Laura B Sagle1, Laura K Ruvuna, Julia A Ruemmele

  • 1Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, IL 60208-3113, USA.

Nanomedicine (London, England)
|October 27, 2011
PubMed
Summary

Localized surface plasmon resonance (LSPR) spectroscopy offers a sensitive method for studying biological interactions. Advancements enable precise detection of molecules and analytes, improving sensing capabilities.

More Related Videos

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Related Experiment Videos

Last Updated: May 28, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Biochemistry

Background:

  • Localized Surface Plasmon Resonance (LSPR) spectroscopy is a sensitive and flexible technique for analyzing biological interactions.
  • Nanoparticle-based sensing has emerged as a powerful tool in biological research.

Purpose of the Study:

  • To describe the fundamental principles of LSPR spectroscopy for sensing applications.
  • To explore methods for optimizing nanoparticle sensors.
  • To present novel applications of LSPR spectroscopy in biological detection.

Main Methods:

  • Utilizing nanoparticle-based LSPR spectroscopy for biological sensing.
  • Tailoring nanoparticle properties to enhance sensing performance.
  • Applying LSPR spectroscopy for detecting small molecules through protein conformational changes.
  • Coupling LSPR with mass spectrometry for analyte identification.

Main Results:

  • Demonstrated detection of small molecules via protein conformational changes using LSPR.
  • Successfully identified bound analytes by combining LSPR with mass spectrometry.
  • Highlighted the benefits of single nanoparticle LSPR, including lower detection limits and nanoscale multiplexing.

Conclusions:

  • LSPR spectroscopy, particularly single nanoparticle LSPR, offers significant advantages for sensitive and versatile biological sensing.
  • Advancements in LSPR enable creative and improved sensing capabilities for various applications.
  • The technique facilitates precise detection and identification of biological molecules and analytes.