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Influence of area 5 on interhemispheric inhibition
Azra Premji1, Chris Zapallow, Philemon Tsang
1Department of Kinesiology, University of Waterloo, Waterloo, Canada.
Neuroreport
|October 27, 2011
Summary
Brodmann's area 5 stimulation enhances short-latency interhemispheric inhibition (IHI) in the left hand. This suggests area 5 influences motor cortex circuitry for hand control.
Area of Science:
- Neuroscience
- Motor Control
- Neurophysiology
Background:
- Brodmann's area 5 plays a role in sensorimotor hand control.
- Its influence on primary motor cortex circuitry for hand control is not well understood.
Purpose of the Study:
- To investigate how area 5 affects interhemispheric inhibition (IHI) between homologous motor cortex representations of the hand.
Main Methods:
- Paired-pulse transcranial magnetic stimulation (TMS) was used to probe IHI.
- Continuous theta-burst stimulation (cTBS) was applied over left area 5.
- IHI was measured for the first dorsal interosseous muscle at short (10 ms) and long (40 ms) latencies before and after cTBS.
Main Results:
- cTBS over left area 5 increased short-latency IHI from left-to-right hemisphere for the left hand.
- This effect persisted for 5-20 min and 45-60 min post-stimulation.
- Short-latency IHI in the right hand and bilateral long-latency IHI were not significantly altered.
Conclusions:
- Brodmann's area 5 influences IHI between motor cortex hand representations.
- The observed effects, occurring ipsilateral to the stimulated area 5, suggest modulation of transcallosal neuron excitability originating in the left motor cortex.
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