Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 28, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Vascular changes in bleomycin-induced scleroderma.

Toshiyuki Yamamoto1, Ichiro Katayama

  • 1Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima 960-1295, Japan.

International Journal of Rheumatology
|October 27, 2011
PubMed
Summary

This study details vascular changes in bleomycin-induced systemic sclerosis (SSc) mouse models. Findings clarify the role of vascular alterations in scleroderma pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circadian Clock Regulates Epidermal Endocrine System in Homeostatic Skin Pigmentation.

Experimental dermatology·2026
Same author

Second Guidelines for the Diagnosis and Treatment of Vitiligo in Japan (2025).

The Journal of dermatology·2026
Same author

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo.

Nature communications·2026
Same author

Salidroside Selectively Binds to SEC23A and Ameliorates Psychological Stress-Induced Hyperpigmentation.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Type I Interferons Induce CD8<sup>+</sup> T Cell Chemotaxis Through Regulating Melanocyte but Not Keratinocyte CXCL9/10/11 Secretion in the Initiation of Vitiligo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Pathogenesis of Chemical Leukoderma and Chemical-Induced Vitiligo.

The Journal of dermatology·2025

Area of Science:

  • Vascular Biology
  • Immunology
  • Fibrosis Research

Background:

  • Systemic sclerosis (SSc) involves vascular injury, immune dysfunction, and fibrosis.
  • Vascular impairment is an early SSc hallmark, crucial to its pathogenesis.
  • Interactions between vascular cells and fibroblasts contribute to SSc vasculopathy.

Purpose of the Study:

  • To investigate vascular alterations in bleomycin-induced murine scleroderma.
  • To detail the role of vascular involvement in this SSc model.

Main Methods:

  • Focus on vascular aspects within the bleomycin-induced scleroderma mouse model.
  • Analysis of cellular interactions and histological features related to vascular changes.

Main Results:

  • Bleomycin induces endothelial cell and fibroblast stimulation.
  • Proinflammatory and fibrogenic cytokines, apoptosis, and reactive oxygen species are implicated.
  • Vascular wall proliferation is a key histological feature in lesional skin.

Conclusions:

  • Vascular alterations are central to bleomycin-induced scleroderma.
  • Understanding these vascular changes offers insights into SSc pathogenesis.
  • This model aids in studying SSc-related vasculopathy.

More Related Videos

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
06:52

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

An Improved Method for Rapid Intubation of the Trachea in Mice
08:46

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016

Related Experiment Videos

Last Updated: May 28, 2026

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
06:52

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Published on: April 30, 2019

An Improved Method for Rapid Intubation of the Trachea in Mice
08:46

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016