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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: May 28, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Inflammation as an animal development phenomenon.

Gustavo Campos Ramos1

  • 1Department of Pharmacology, Biological Sciences Centre, Federal University of Santa Catarina, 88049-900 Florianópolis, SC, Brazil. ramosgc@gmail.com

Clinical & Developmental Immunology
|October 27, 2011
PubMed
Summary
This summary is machine-generated.

Inflammation, traditionally viewed as a defense mechanism or disease process, is proposed here as a key driver of animal development. This perspective reframes inflammation as a fundamental physiological process integral to form generation and regeneration.

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Published on: May 16, 2016

Area of Science:

  • Developmental Biology
  • Immunology
  • Physiology

Background:

  • Inflammation is historically understood as a clinical symptom, disease mechanism, or defense against microbes.
  • Existing explanations often overlook its role in broader biological processes.

Purpose of the Study:

  • To propose a novel perspective on inflammation.
  • To integrate inflammation within the framework of developmental biology.

Main Methods:

  • Conceptual analysis integrating immunological, pathological, and developmental contexts.
  • Re-evaluation of established scientific principles in bacteriology and evolutionary biology.

Main Results:

  • Inflammatory events can be reinterpreted as mechanisms of animal development.
  • The generation, conservation, and regeneration of animal form share common inflammatory underpinnings.

Conclusions:

  • Inflammation possesses a significant, yet neglected, physiological role.
  • Viewing inflammation through a developmental biology lens offers new insights into its function.