T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age-Related Diseases

Area of Science:

• Immunology
• Cardiology
• Computational Biology

Background:

• Cardiovascular diseases (CVD) are influenced by complex immune system interactions.
• Antigen-specific T cell responses are critical in conditions like atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis.
• Understanding T cell receptor (TCR) repertoires is key to elucidating CVD mechanisms.

Purpose of the Study:

• To review T cell-dependent mechanisms and TCR clonal dynamics in various CVD.
• To present the first cardiovascular disease T cell receptor (CVD-TCR) database.
• To promote integrated understanding and computational modeling of immune responses in CVD.

Main Methods:

• Review of existing literature on T cell mechanisms in CVD.
• Curation of public bulk and single-cell TCR sequencing datasets.
• Development of the CVD-TCR database.

Main Results:

• Identification of T cell clonal dynamics as a significant factor in CVD.
• Establishment of a comprehensive CVD-TCR database integrating diverse datasets.
• Framework for analyzing shared TCR clonotypes and motifs across CVD.

Conclusions:

• TCR repertoire analysis provides valuable mechanistic insights into CVD.
• The CVD-TCR database serves as a resource for understanding tissue-specific immunity in heart diseases.
• This work facilitates the development of targeted immunomodulatory diagnostics and therapeutics for cardiovascular conditions.