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Salivary PYY: a putative bypass to satiety
Andres Acosta1, Maria D Hurtado, Oleg Gorbatyuk
1Pediatrics, University of Florida, Gainesville, Florida, United States of America.
Peptide YY(3-36), a gut hormone, is found in saliva and enhances satiation. Increasing salivary Peptide YY(3-36) in mice reduced food intake and body weight, suggesting a new obesity treatment strategy.
Area of Science:
- Endocrinology
- Gastroenterology
- Physiology
Background:
- Peptide YY(3-36) (PYY) is a known gut satiation hormone released after meals.
- PYY's presence and function in saliva have not been previously established.
Purpose of the Study:
- To investigate the presence and role of PYY(3-36) in saliva.
- To explore the therapeutic potential of salivary PYY(3-36) for obesity treatment.
Main Methods:
- Detection of PYY(3-36) in murine and human saliva.
- Feeding behavioral studies in mice to assess satiation.
- Viral vector-mediated gene delivery to increase salivary PYY(3-36) in diet-induced obese mice.
Main Results:
- PYY(3-36) is present in saliva, derived from plasma and synthesized in tongue taste cells.
- Increased salivary PYY(3-36) enhanced satiation via Y2 receptor activation in lingual epithelial cells.
- Sustained elevation of salivary PYY(3-36) led to significant long-term reductions in food intake and body weight in obese mice.
Conclusions:
- Saliva contains functional PYY(3-36) that influences satiation.
- Targeting salivary PYY(3-36) offers a novel therapeutic approach for obesity management.
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