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Related Experiment Video

Updated: May 28, 2026

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
06:20

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Published on: December 5, 2020

Sheehan's syndrome: Newer advances.

C Shivaprasad1

  • 1Department of Endocrinology, M. S. Ramaiah Hospital, Bangalore, India.

Indian Journal of Endocrinology and Metabolism
|October 27, 2011
PubMed
Summary

Sheehan's syndrome (SS) is a rare postpartum pituitary gland necrosis causing hormone deficiency. Early diagnosis and treatment are crucial for patient outcomes, especially in developing regions.

Area of Science:

  • Endocrinology
  • Obstetrics & Gynecology
  • Reproductive Medicine

Background:

  • Sheehan's syndrome (SS) is a condition of postpartum hypopituitarism resulting from pituitary gland necrosis.
  • It is typically caused by severe hypotension or shock due to massive obstetric hemorrhage.
  • Patients present with varying degrees of anterior pituitary hormone deficiency.

Purpose of the Study:

  • To summarize the etiology, clinical presentation, and diagnostic clues of Sheehan's syndrome.
  • To highlight the decreasing incidence in developed nations due to improved obstetric care.
  • To emphasize its continued prevalence and importance in underdeveloped and developing countries.

Main Methods:

  • Literature review of Sheehan's syndrome.
  • Analysis of clinical presentation and diagnostic factors.
Keywords:
Lactation failureSheehanpituitary necrosispostpartum hemorrhage

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  • Discussion of epidemiological trends and management implications.

    • Main Results:

    • SS frequency is declining globally, particularly in developed countries, due to advances in obstetric care.
    • The condition remains prevalent in underdeveloped and developing regions.
    • Delayed diagnosis is common due to the slow evolution of symptoms.

    Conclusions:

    • Sheehan's syndrome is a significant cause of hypopituitarism, particularly in resource-limited settings.
    • Key diagnostic indicators include a history of postpartum hemorrhage, failure to lactate, and amenorrhea.
    • Timely diagnosis and management are essential to mitigate patient morbidity and mortality.