Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spectroscopic correlation tomography (SpCT) for visualization of spatial correlations in volumetric OCT scans.

Biomedical optics express·2026
Same author

On-Chip Cavity Electroacoustics Using Lithium Niobate Phononic Crystal Resonators.

Physical review letters·2026
Same author

Microwave-acoustic-based isolated gate driver for power electronics.

Communications engineering·2026
Same author

Real-time processing of high-throughput quantitative phase microscopy data using a Jetson Orin Nano.

Biophotonics discovery·2026
Same author

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy <i>in vivo</i> enabled by absorbing dye molecules.

Optica·2026
Same author

Prospective Identification of Dysplasia in Barrett's Esophagus With Combined Optical Coherence Tomography and Light Scattering Measurements.

Journal of biophotonics·2025

Related Experiment Video

Updated: Dec 22, 2025

Label-free, High-Resolution 3D Imaging and Machine Learning Analysis of Intestinal Organoids via Low-Coherence Holotomography
10:40

Label-free, High-Resolution 3D Imaging and Machine Learning Analysis of Intestinal Organoids via Low-Coherence Holotomography

Published on: August 12, 2025

1.3K

Detection of intestinal dysplasia using angle-resolved low coherence interferometry.

Neil Terry1, Yizheng Zhu, Julie K M Thacker

  • 1Duke University, Department of Biomedical Engineering, 136 Hudson Hall, Durham, North Carolina 27708, USA. neil.terry@duke.edu

Journal of Biomedical Optics
|October 28, 2011
PubMed
Summary

Angle-resolved low coherence interferometry (a/LCI) can detect intestinal dysplasia by measuring cell nuclei size and density. This optical biopsy technique shows promise for identifying precancerous changes in the colon.

More Related Videos

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

8.6K
Diagnosis of Neoplasia in Barrett&#8217;s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

12.3K

Related Experiment Videos

Last Updated: Dec 22, 2025

Label-free, High-Resolution 3D Imaging and Machine Learning Analysis of Intestinal Organoids via Low-Coherence Holotomography
10:40

Label-free, High-Resolution 3D Imaging and Machine Learning Analysis of Intestinal Organoids via Low-Coherence Holotomography

Published on: August 12, 2025

1.3K
Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
07:38

Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing

Published on: September 13, 2016

8.6K
Diagnosis of Neoplasia in Barrett&#8217;s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

12.3K

Area of Science:

  • Biomedical Optics
  • Optical Biopsy
  • Gastrointestinal Pathology

Background:

  • Angle-resolved low coherence interferometry (a/LCI) is an optical biopsy technique.
  • a/LCI enables label-free, depth-resolved measurement of cell nuclei.
  • Previously used for Barrett's Esophagus dysplasia detection.

Purpose of the Study:

  • Evaluate a/LCI for identifying intestinal dysplasia ex vivo.
  • Assess correlation between nuclear morphology and dysplasia.
  • Determine a/LCI's diagnostic performance in colonic tissues.

Main Methods:

  • Pilot ex vivo study on 27 patients undergoing colonic resection.
  • Collected a/LCI measurements from colonic tissues.
  • Compared a/LCI data with histopathological assessment of biopsies.

Main Results:

  • Significant correlation between increased nuclear size and reduced density with dysplasia.
  • Dysplasia identified at the basal layer (200-300 μm depth).
  • Achieved 92.9% sensitivity, 83.6% specificity, and 85.2% accuracy.

Conclusions:

  • a/LCI effectively detects intestinal dysplasia in ex vivo colonic tissues.
  • Demonstrates potential for optical biopsy in colorectal cancer screening.
  • Highlights the need for future in vivo studies to validate findings.