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Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
Anxiety: Overview01:18

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Social Anxiety Disorder01:28

Social Anxiety Disorder

Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
Anxiolytic Drugs: Overview01:26

Anxiolytic Drugs: Overview

Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...

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Related Experiment Video

Updated: May 28, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

Generalised anxiety disorder.

Christopher K Gale1, Jane Millichamp

  • 1Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

BMJ Clinical Evidence
|October 28, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for generalized anxiety disorder (GAD), finding various interventions like antidepressants and cognitive behavioral therapy effective. Further research is needed to confirm long-term safety and efficacy for GAD patients.

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Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Related Experiment Videos

Last Updated: May 28, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat
11:18

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

Reducing State Anxiety Using Working Memory Maintenance
08:17

Reducing State Anxiety Using Working Memory Maintenance

Published on: July 19, 2017

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Generalized anxiety disorder (GAD) affects up to 20% of the population, often co-occurring with other health issues.
  • Full remission from GAD is achieved by less than half of individuals within five years.
  • Potential contributing factors to GAD include genetic predisposition and history of psychological trauma.

Purpose of the Study:

  • To systematically review and evaluate the effects of various treatments for generalized anxiety disorder (GAD).
  • To synthesize evidence on the effectiveness and safety of pharmacological and non-pharmacological interventions for GAD.

Main Methods:

  • Conducted a systematic literature review up to May 2011, searching major databases (Medline, Embase, Cochrane Library).
  • Included data from 74 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated safety information from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified numerous interventions for GAD, including antidepressants (e.g., duloxetine, sertraline), benzodiazepines, and cognitive behavioral therapy.
  • Assessed the quality of evidence for different interventions using the GRADE system.
  • Compiled data on the effectiveness and safety profiles of evaluated treatments.

Conclusions:

  • The review presents findings on the effectiveness and safety of diverse GAD interventions.
  • Interventions covered include abecarnil, specific antidepressants, antipsychotics, applied relaxation, benzodiazepines, buspirone, cognitive behavioral therapy, hydroxyzine, and pregabalin.
  • This systematic review serves as a resource for understanding current treatment options for GAD.