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Related Experiment Video

Updated: May 28, 2026

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

Published on: September 12, 2014

Generalised anxiety disorder.

Christopher K Gale¹, Jane Millichamp

¹Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

BMJ Clinical Evidence

|October 28, 2011

Summary

This summary is machine-generated.

This systematic review evaluates treatments for generalized anxiety disorder (GAD), finding various interventions like antidepressants and cognitive behavioral therapy effective. Further research is needed to confirm long-term safety and efficacy for GAD patients.

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Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

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Published on: September 12, 2014

Reducing State Anxiety Using Working Memory Maintenance

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Published on: July 19, 2017

Area of Science:

Psychiatry
Clinical Psychology
Pharmacology

Background:

Generalized anxiety disorder (GAD) affects up to 20% of the population, often co-occurring with other health issues.
Full remission from GAD is achieved by less than half of individuals within five years.
Potential contributing factors to GAD include genetic predisposition and history of psychological trauma.

Purpose of the Study:

To systematically review and evaluate the effects of various treatments for generalized anxiety disorder (GAD).
To synthesize evidence on the effectiveness and safety of pharmacological and non-pharmacological interventions for GAD.

Main Methods:

Conducted a systematic literature review up to May 2011, searching major databases (Medline, Embase, Cochrane Library).
Included data from 74 systematic reviews, randomized controlled trials (RCTs), and observational studies.
Incorporated safety information from regulatory agencies like the FDA and MHRA.

Main Results:

Identified numerous interventions for GAD, including antidepressants (e.g., duloxetine, sertraline), benzodiazepines, and cognitive behavioral therapy.
Assessed the quality of evidence for different interventions using the GRADE system.
Compiled data on the effectiveness and safety profiles of evaluated treatments.

Conclusions:

The review presents findings on the effectiveness and safety of diverse GAD interventions.
Interventions covered include abecarnil, specific antidepressants, antipsychotics, applied relaxation, benzodiazepines, buspirone, cognitive behavioral therapy, hydroxyzine, and pregabalin.
This systematic review serves as a resource for understanding current treatment options for GAD.