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Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe
Tae-Il Kim1, Jihye Park, Seonhwa Park
1Department of Chemistry, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do, 448-701, Korea.
Chemical Communications (Cambridge, England)
|October 28, 2011
Abstract:
We have presented a fluorescent probe 1 that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it is readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activity in buffered aqueous solution, and further utilized for the visualization of endogenous tyrosinase activity in living melanoma cells.
