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Related Experiment Video

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Fatty filum with different histological features. Case report.

Y Izci¹, S Pusat, O Onguru

¹Departments of Neurosurgery, Gulhane Military Medical Academy, Turkey.

Neurocirugia (Asturias, Spain)

|October 28, 2011

Summary

This study reports a rare case of split cord malformation coexisting with a fatty filum terminale in a child. The distinct histological findings in this case suggest a potential link between these spinal malformations.

Area of Science:

Neuroscience
Developmental Biology
Pediatric Neurosurgery

Background:

Split cord malformation (SCM) and fatty filum terminale (FFT) are distinct spinal dysraphic abnormalities.
Typically, these conditions are considered to have separate pathophysiological origins.
Accurate diagnosis and management require recognition of these separate entities.

Observation:

A 3-year-old boy presented with skin lesions and leg weakness, indicating a possible spinal malformation.
MRI revealed type II SCM with syringomyelia, tethered cord, and FFT.
Surgical intervention involved addressing both the SCM and the FFT.

Findings:

Histopathological examination of the FFT demonstrated an unusual combination of bone, fat, ciliated epithelial cells, and meningothelial proliferation.

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This histological pattern for FFT is novel and has not been previously reported.

The co-occurrence of type II SCM and this unique FFT histology was observed.

Implications:

This case challenges the traditional understanding of SCM and FFT as entirely unrelated conditions.
The unique histological findings in the FFT raise questions about potential shared or causative relationships between these pathologies.
Further research is warranted to explore the potential association between SCM and FFT, particularly with atypical histological features.