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Related Concept Videos

Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Distribution of Cytoplasmic Content02:33

Distribution of Cytoplasmic Content

Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...

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Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Cytokinesis: cells go back and forth about division.

Jonas F Dorn1, Amy Shaub Maddox

  • 1Institute for Research in Immunology and Cancer, Université de Montréal, Station Centre-Ville Montréal QC, H3C 3J7 Canada. jonas.dorn@umontreal.ca

Current Biology : CB
|October 29, 2011
PubMed
Summary

This study presents a quantitative model for cellular oscillations in cytokinesis, uncovering a new role for polar blebbing. It questions the cell

Area of Science:

  • Cell Biology
  • Quantitative Biology
  • Biophysics

Background:

  • Cytokinesis, the process of cell division, involves complex cellular dynamics.
  • Cellular oscillations are critical for proper cell division.
  • The role of polar blebbing in cytokinesis remains incompletely understood.

Purpose of the Study:

  • To develop a quantitative model explaining cellular oscillations during cytokinesis.
  • To elucidate a novel function for polar blebbing in this process.
  • To investigate the biological significance of cells operating at critical thresholds.

Main Methods:

  • Development of a mathematical model for cell division dynamics.
  • Simulation of cellular oscillations and polar blebbing.
  • Analysis of model parameters related to cell edge stability.

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Last Updated: May 28, 2026

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
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Main Results:

  • The model successfully explains observed cellular oscillations during cytokinesis.
  • A novel function for polar blebbing in regulating oscillation stability was identified.
  • The findings suggest cells operate near a critical stability point.

Conclusions:

  • Polar blebbing plays a crucial, previously unrecognized role in controlling cytokinesis oscillations.
  • Cells may be optimized to function at the edge of stability for regulatory efficiency.
  • Further research is needed to understand the evolutionary advantage of this 'edge-living' strategy.