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Chronic obstructive pulmonary disease: a concise review.
Ron Balkissoon1, Steve Lommatzsch, Brendan Carolan
1National Jewish Health, Pulmonary Division, Department of Medicine, Denver, CO 80206, USA. balkissoonr@NJHealth.org
Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally and in the US. Research highlights COPD
Area of Science:
- Pulmonology and Respiratory Medicine
- Genetics and Pathogenesis
- Clinical Trials and Therapeutics
Background:
- Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality.
- COPD is the third leading cause of death in the United States.
- Recent advancements include extensive research into COPD genetics and pathogenesis.
Purpose of the Study:
- To review recent advancements in COPD research.
- To discuss new treatment paradigms introduced by large-scale clinical trials.
- To emphasize the extrapulmonary manifestations and comorbidities of COPD.
Main Methods:
- Review of bench and translational research over the past 15 years.
- Analysis of findings from large-scale clinical trials.
- Evaluation of current research on COPD pathogenesis and extrapulmonary effects.
Main Results:
- Significant progress in understanding COPD genetics and pathogenesis.
- Introduction of novel treatment strategies through clinical trials.
- Recognition of COPD as a systemic disease with extrapulmonary involvement.
Conclusions:
- COPD requires a comprehensive approach, considering both pulmonary and extrapulmonary aspects.
- Ongoing research continues to refine our understanding and treatment of COPD.
- Early evaluation and treatment of comorbidities are crucial for managing COPD patients.
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