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Chronic obstructive pulmonary disease: a concise review
Ron Balkissoon1, Steve Lommatzsch, Brendan Carolan
1National Jewish Health, Pulmonary Division, Department of Medicine, Denver, CO 80206, USA. balkissoonr@NJHealth.org
Abstract:
Globally, chronic obstructive pulmonary disease (COPD) is a major cause of significant morbidity and mortality, and is now the third leading cause of death in the United States. Over the past 15 years there has been a surge of bench and translational research regarding the genetics and pathogenesis of COPD, and several large-scale clinical trials have introduced new treatment paradigms for COPD. Current research also demonstrates that COPD is not just a lung disease and that there are several potential extrapulmonary manifestations and comorbidities that should be evaluated and treated when one identifies an individual as having COPD.
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